組蛋白的甲基化、乙?;土姿峄确g后修飾(PTM)是調節基因表達調控、DNA修復、染色體凝縮和精子形成的關鍵步驟。目前,已經確認許多蛋白能夠形成復合物,起到調節組蛋白修飾的作用。 這些組蛋白修飾復合物的功能變化被認為破壞了組蛋白標記的結構和水平,從而解除了基于核染色質的過程控制,最終導致致癌轉化和癌癥的發展。與此一致的是,組蛋白PTM的異常模式與大量的人類惡性腫瘤有關。
眾所周知,組蛋白的翻譯后修飾(PTM)在表觀遺傳調控中發揮重要作用,研究組蛋白PTM過程中抗體是很重要的一環,組蛋白PTM的抗體是表觀遺傳學研究(如染色質免疫沉淀(ChIP)、免疫染色和免疫印跡)中的關鍵元素。然而,目前市面上許多組蛋白PTM抗體不能特異識別預定目標。今天小艾給大家帶來知名品牌Rockland專利的組蛋白修飾相關抗體——Epi-Plus?系列抗體,期望Epi-Plus?憑借其無與倫比靈敏度和特異性給廣大科研工作者組蛋白PTM研究帶來新助力。
Rockland Epi-Plus?特點及優勢:
Rockland的高特異性Epi-Plus?系列抗體可識別經過修飾的組蛋白和相關的細胞靶點,并通過多種檢測方法進行驗證。Epi-Plus?抗體對這種修飾是特別靈敏和特異的,并且對相同位點或該蛋白其他氨基酸的其他修飾沒有交叉反應。免疫熒光(IF)、免疫沉淀(IP)、染色質免疫沉淀(ChIP)、免疫組化(IHC)和蛋白印跡(WB)的分析驗證了Epi-Plus?抗體的有效性。
Histone 3 K4 甲基化相關抗體:
貨號 | 名稱 | 規格 |
600-401-I57 | Anti-Histone H3 [Monomethyl Lys4] (RABBIT) Antibody | 50ug |
600-401-I58 | Anti-Histone H3 [Dimethyl Lys4] (RABBIT) Antibody | 50ug |
600-401-I59 | Anti-Histone H3 [Trimethyl Lys4] (RABBIT) Antibody | 50ug |
Epi-Plus? 其他組蛋白修飾抗體推薦:
貨號 | 名稱 | 規格 | 種屬反應 |
600-401-I52 | Histone H3 R2me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I53 | Histone H3 R2me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I54 | Histone H3 K4me1/pT3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I55 | Histone H3 K4me2/pT3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I56 | Histone H3 pT3/K4ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I57 | Histone H3 K4me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I58 | Histone H3 K4me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I59 | Histone H3 K4me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I60 | Histone H3 K4ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I61 | Histone H3 K4me1/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I62 | Histone H3 K4me3/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I63 | Histone H3 pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I64 | Histone H3 K9me1/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I65 | Histone H3 K9me2/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I66 | Histone H3 K9me3/pT6 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I67 | Histone H3 R8me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I68 | Histone H3 R8me2s Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I69 | Histone H3 K9me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I70 | Histone H3 K9me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I71 | Histone H3 K9me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I72 | Histone H3 K9ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I73 | Histone H3 K9ac/K14ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I74 | Histone H3 pS10 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I75 | Histone H3 pS10/pT11 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I76 | Histone H3 pT11 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I77 | Histone H3 R17me2a Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I78 | Histone H3 K18me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I79 | Histone H3 K18me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I80 | Histone H3 K18me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I81 | Histone H3 K18ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I82 | Histone H3 K23ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I83 | Histone H3 pS28 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I84 | Histone H3 K27me3/pS28 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I85 | Histone H3 R2me2s/K4me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I86 | Histone H3 K36me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I87 | Histone H3 K36me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I88 | Histone H3 K36me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I89 | Histone H3 K36ac Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I90 | Histone H3 K37me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I91 | Histone H3 K37me2 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I92 | Histone H3 K37me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I93 | Histone H3 K56me1 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I94 | Histone H3 K56me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-I95 | Histone H3 K79Me3 Antibody | 50ug | Human, mouse, C. elegans, rat, chicken, Xenopus, Drosophila, plant |
600-401-J98 | Histone H3 K4-Me3/K9-Ac Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-J99 | Histone H3 K27me3 Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-K00 | Histone H3 K27ac Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-K01 | Histone H3 K4me2/pT6 Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-K02 | Histone H3 K23me2 Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-M75 | Histone H3 K27 methyl Antibody | 50ug | Human, mouse, rat, C. elegans |
600-401-P08 | Histone H3 K9-Ac/pS10 (RABBIT) Antibody | 50ug | Human |
600-401-P10 | Histone H3 K79-Me1 Antibody | 50ug | Human, Mouse, Primate, C. elegans, Drosophila, Plant, Rat, Xenopus |
600-401-P14 | Histone H3 pT3/R2-Me2s Antibody | 50ug | Human |
600-401-V34 | Histone H3 K27 me2 Antibody | 50ug | Human |
600-401-W54 | Histone H3 K27 me1 Antibody | 50ug | Human |
*以上產品僅供科研使用,不得用于醫療及診斷.
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